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Integrated stress response : ウィキペディア英語版
Integrated stress response
Integrated Stress Response (ISR) is a cellular stress response common to all eukaryotes. ISR is a common denominator of different types of cellular stresses resulting in activation of at least one of the eIF-2 alpha (EIF2S1).
ISR results in the:
*Down regulation of the general protein synthesis (CAP-dependent)
*Up regulation of translation and expression of certain transcription factors, e.g. Activating Transcription Factor 4 (ATF4)
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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